MyBioSource.com's TBX21 Antibody (N-term) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunofluorescence, and Western Blot. The TBX21 Antibody (N-term) was generated using T-bet, T-box 21, T-box transcription factor TBX21-like, TBET, TBLYM, and TBX21 as the antigen and it reacts with Human.
Description
This gene is a member of a phylogenetically conserved
family of genes that share a common DNA-binding domain, the T-box.
T-box genes encode transcription factors involved in the regulation
of developmental processes. This gene is the human ortholog of
mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is
a Th1 cell-specific transcription factor that controls the
expression of the hallmark Th1 cytokine, interferon-gamma (IFNG).
Expression of the human ortholog also correlates with IFNG
expression in Th1 and natural killer cells, suggesting a role for
this gene in initiating Th1 lineage development from naive Th
precursor cells